Synthesis of 24‐h soluble gelatin sponge particles and their effect on liver necrosis following hepatic artery embolization: Results of <i>in vitro</i> and <i>in vivo</i> studies

Sanda, Hiroki; Kawai, Nobuyuki; Sato, Morio; Tanaka, Fumihiro; Ikoma, Akira; Nakaï, Motoki; Minamiguchi, Hiroki; Sonomura, Tetsuo; Matsuzaki, Ibu; Warigaya, Kenji; Murata, Shin‐ichi

doi:10.1111/hepr.12539

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…23 SGS was prepared from RMG by changing the temperature at which the cross-links are formed and by controlling the dissolution time in saline. 22,24 Takasaka et al reported that hepatic arteries were completely recanalized at 2 days after embolization using SGS (50 kDa, heat-induced cross-linking at 138 C) without the development of collateral pathways in swine. 23 Kawai et al reported that TACE using 2D-SGS had similar therapeutic effects and adverse effects to those of TACE using insoluble gelatin sponge particles while causing significantly less hepatic artery impairment.…”

Section: Discussionmentioning

confidence: 99%

“…In 2007, we developed an RMG with extremely low endotoxicity and antigenicity 23 . SGS was prepared from RMG by changing the temperature at which the cross‐links are formed and by controlling the dissolution time in saline 22,24 . Takasaka et al .…”

Section: Discussionmentioning

confidence: 99%

“… 23 SGS was prepared from RMG by changing the temperature at which the cross‐links are formed and by controlling the dissolution time in saline. 22 , 24 Takasaka et al . reported that hepatic arteries were completely recanalized at 2 days after embolization using SGS (50 kDa, heat‐induced cross‐linking at 138°C) without the development of collateral pathways in swine.…”

Section: Discussionmentioning

confidence: 99%

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Impact of anticancer drugs on the therapeutic efficacy and side effects of hepatic arterial embolization for hepatocellular carcinoma

Ihira,

Sonomura,

Makitani

et al. 2023

JGH Open

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Background and AimTranscatheter arterial chemoembolization (TACE) using various anticancer drugs is often performed to treat hepatocellular carcinoma (HCC). We aimed to compare the therapeutic efficacy and side effects of TACE with anticancer drugs versus transcatheter arterial embolization (TAE) without anticancer drugs for HCC.MethodsPatients with HCC were randomized to either the TACE or TAE group. Up to five target nodules were treated in each patient. Lipiodol (Lp; 10 mL), contrast media (CM; 10 mL), epirubicin (40 mg), mitomycin C (10 mg), miliplatin (70 mg), and 1–2‐mm 2‐day soluble gelatin sponge particles (2D‐SGS) were injected into the TACE group, whereas Lp (10 mL), CM (10 mL), and 2D‐SGS were injected into the TAE group. Treatment effect (TE) of the target nodules was graded (TE1–TE4) and patient responses were assessed. Three months after treatment, blood tests were performed to compare tumor markers and adverse events.ResultsFifty‐four patients and 161 target nodules were included; 75 nodules in 28 patients were treated by TACE, and 86 nodules in 26 patients were treated by TAE. The number of nodules graded TE1, TE2, TE3, and TE4 was 1, 28, 7, and 39, respectively, in the TACE group and 2, 25, 7, and 52, respectively, in the TAE group. The response rates were 89% (25/28) and 73% (19/26) in the TACE and TAE groups, respectively. There were no significant differences in TE, response rates, or blood test results between the two groups.ConclusionIn hepatic arterial embolization for HCC, anticancer drugs did not have any impact on the therapeutic efficacy or side effects at 3 months after embolization.

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