“…Since its inception in the 1920s, the Diels–Alders (DA) reaction has been employed extensively in the formation of six‐membered rings. Today, this discovery empowers scientists in both fundamental research and the production of natural products and pharmaceuticals . Employing palladacycle 1 and its derivatives as reaction promoters, our group has extensively studied the asymmetric Diels–Alders reaction between 3,4‐dimethyl‐1‐phenylphosphole (DMPP) and a series of functionalized olefins to produce P*‐phosphanorbornenes 6 (Scheme ).…”
Section: Orthometalated Azapalladacycles: From Resolving Agents To Rementioning
Our journey in organophosphorus research over the past 26 years is compiled in this Personal Account. Advances in palladacycle design have engendered a shift in our focus from template-mediated transformations to catalysis for the direct preparation of chiral phosphines containing a wide variety of functional groups. Novel approaches to access previously inaccessible phosphines and their applications in cancer research are summarized herein.
“…Since its inception in the 1920s, the Diels–Alders (DA) reaction has been employed extensively in the formation of six‐membered rings. Today, this discovery empowers scientists in both fundamental research and the production of natural products and pharmaceuticals . Employing palladacycle 1 and its derivatives as reaction promoters, our group has extensively studied the asymmetric Diels–Alders reaction between 3,4‐dimethyl‐1‐phenylphosphole (DMPP) and a series of functionalized olefins to produce P*‐phosphanorbornenes 6 (Scheme ).…”
Section: Orthometalated Azapalladacycles: From Resolving Agents To Rementioning
Our journey in organophosphorus research over the past 26 years is compiled in this Personal Account. Advances in palladacycle design have engendered a shift in our focus from template-mediated transformations to catalysis for the direct preparation of chiral phosphines containing a wide variety of functional groups. Novel approaches to access previously inaccessible phosphines and their applications in cancer research are summarized herein.
“…Die Strategie auf Grundlage des Prinzips der Schutzgruppeneinführung im 5,7‐Diensystem wurde von Barton, Hesse et al. hinsichtlich der Verwendung von Schwefeldioxid weiter ausgebaut,39 inspiriert durch eine wegweisende Arbeit von Staudinger und Ritzenthaler aus dem Jahr 1935 40. Die cheletrope [4+1]‐Addition von SO 2 an ein 1,3‐konjugiertes Dien kann im Rahmen dieses Aufsatzes zu [4+2]‐DA‐Reaktionen nicht behandelt werden.…”
Considering that rice bran is cheap and commercially available and that rice bran GAD is relatively stable, the development of cost-effective rice bran GAD-related functional foods would seem to be feasible.
“…The strategy, based on the principle of protecting the 5,7‐diene system, was extended to the use of sulfur dioxide by Barton, Hesse, and co‐workers,39 inspired by the pioneering work of Staudinger and Ritzenthaler in 1935 40. The [4+1] cheletropic addition of SO 2 onto a 1,3‐conjugated diene is beyond the scope of this Review devoted to [4+2] DA reactions.…”
Section: Active Pharmaceutical Ingredientsmentioning
The proposed method was successfully applied to the determination of Sudan IV in contaminated hot chilli powder, with recoveries ranging from 89.3 to 108.4%. The possible mechanism of enhancement of the luminol/dissolved oxygen CL reaction by Sudan IV can be attributed to the acceleration of electron transfer. Compared with other procedures, the proposed CL method offers the highest sensitivity and the least reagent consumption for the determination of Sudan IV.
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