Synthesis of 3-{3-[(4-methylcyclohex-3-enyl-carbonyl)amino]-4-oxo-3,4-dihydroquinazolin-2-yl}propanoic acid anilides

Synthesis of 2-Amino-N′-aroyl(het)arylhydrazides, DNA Photocleavage, Molecular Docking and Cytotoxicity Studies against Melanoma CarB Cell Lines

“…The activity among the AA DACHZs of this group (5-8) indicated again that the nitroaryl moiety lowered DNA photocleavage (derivative 7). What was left to be analyzed was the group of the 5-Br-AA DACHZs (9-12), of the 3,5-diBr-AA DACHZs (13-16) and of the 5-I-AA DACHZs (17,18). In addition to the compound 9 (2 µM), the rest of the derivatives 10-18 were active at a concentration of 10 µM.…”

“…The attachment of Anthranilic acid DACHZs (AA DACHZs, Figure 2, G, H) bear an additional functional amine group which contributes to their chemistry, biology and technology. Derivatives such as G may give rise to 1,3,4-oxadiazoles [7][8][9][10], 1,2,3-benzotriazine-4-ones [11], 3-amido-1,2dihydro substituted quinazolinones [12][13][14][15][16][17], 3-amido substituted quinazolinones [10,18], quinazolinone containing fused polycyclic compounds [19,20] or N-N axially chiral 3,3 ′bisquinazolinones [21]. Furthermore, their well-positioned electron-donating atoms allow metal complexation which, depending on the metal and the conditions applied, range from the formation of simple metal complexes [22][23][24] to the important metal-organic macrocycles (MOMs) [25,26] with Mn, Ga and In [27][28][29].…”