Synthesis of 3,3′-bisindoles <i>via</i> demethylenation

Chen, Hui; Cui, Ranran; Zhang, Yahui; Gao, Yu; Chen, Haijun

doi:10.1039/d2qo01010k

Org. Chem. Front.

2022

DOI: 10.1039/d2qo01010k

|View full text |Cite

Synthesis of 3,3′-bisindoles via demethylenation

Hui Chen

Ranran Cui

Yahui Zhang

et al.

Abstract: Herein, we report a mild and metal-free for the synthesis of 3,3'-bisindoles. The transformation proceeds through the removal of Fmoc group followed by the loss of a methylene unit via...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

2,3′‐Bisindole Synthesis fromo‐(2.2‐Dibromovinyl)aniline ando‐Ethynylaniline

Yang

Song

et al. 2023

Asian J Org Chem

View full text Add to dashboard Cite

A Pd‐catalyzed coupling reaction from o‐alkynylanilines and o‐(2,2‐dibromovinyl)anilines for the synthesis of 2,3′‐bisindoles is developed. In which, o‐ethynylaniline was used as 3‐functionalized indole precursor and o‐(2,2‐dibromovinyl)aniline was used as 2‐functionalized indole precursor. This protocol exhibits high efficiency, good functional group tolerance and scalability from easily accessible starting materials.

show abstract

2,3′‐Bisindole Synthesis fromo‐(2.2‐Dibromovinyl)aniline ando‐Ethynylaniline

Yang

Song

et al. 2023

Asian J Org Chem

View full text Add to dashboard Cite

show abstract

Green Late‐Stage Functionalization of Tryptamines

Xu,

Zhang,

Cai

et al. 2024

Chemistry A European J

View full text Add to dashboard Cite

An efficient and rapid protocol for the oxidative halogenation of tryptamines with 10% aqueous NaClO has been developed. This reaction is featured by its operational simplicity, metal‐free conditions, no purification, and high yield. Notably, the resulting key intermediates are suitable for further functionalization with various nucleophiles, including amines, N‐aromatic heterocycles, indoles and phenols. The overall transformation exhibits broad functional‐group tolerance and is applicable to the late‐stage functionalization of complex biorelevant molecules.

show abstract

Recent advances on the synthesis and application of tetrahydro-γ-carbolines

Mei

Aradi

Kiss

et al. 2023

Chinese Chemical Letters

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis of 3,3′-bisindoles via demethylenation

Abstract: Herein, we report a mild and metal-free for the synthesis of 3,3'-bisindoles. The transformation proceeds through the removal of Fmoc group followed by the loss of a methylene unit via...

Cited by 5 publications

References 31 publications

2,3′‐Bisindole Synthesis fromo‐(2.2‐Dibromovinyl)aniline ando‐Ethynylaniline

2,3′‐Bisindole Synthesis fromo‐(2.2‐Dibromovinyl)aniline ando‐Ethynylaniline

Green Late‐Stage Functionalization of Tryptamines

Recent advances on the synthesis and application of tetrahydro-γ-carbolines

Contact Info

Product

Resources

About