Synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by nafion-H under ultrasound irradiation and solvent-free conditions

Wang, Q.; Pan, Wanling

doi:10.1007/bf03246016

Cited by 11 publications

(1 citation statement)

References 18 publications

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“…55 In 2010, Wang and co-workers demonstrated a new approach involving the use of Nafion-H catalyst under ultraviolet irradiation and solvent free conditions (Table 1). 56 The reaction mixture containing Nafion-H catalyst was irradiated in the water bath of an ultrasonicator for some time (not specified). The catalyst was simply separated by filtration.…”

Section: Acs Combinatorial Sciencementioning

confidence: 99%

Biginelli Reaction: Polymer Supported Catalytic Approaches

et al. 2019

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The Biginelli product, dihydropyrimidinone (DHPM) core, and its derivatives are of immense biological importance. There are several methods reported as modifications to the original Biginelli reaction. Among them, many involve the use of different catalysts. Also, among the advancements that have been made to the Biginelli reaction, improvements in product yields, less hazardous reaction conditions, and simplified isolation of products from the reaction predominate. Recently, solid-phase synthetic protocols have attracted the research community for improved yields, simplified product purification, recyclability of the solid support, which forms a special economic approach for Biginelli reaction. The present Review highlights the role of polymer-supported catalysts in Biginelli reaction, which may involve organic, inorganic, or hybrid polymers as support for catalysts. A few of the schemes involve magnetically recoverable catalysts where work up provides green approach relative to traditional methods. Some research groups used polymer−catalyst nanocomposites and polymer-supported ionic liquids as catalyst. Solvent-free, an ultrasound or microwave-assisted Biginelli reactions with polymer-supported catalysts are also reported.

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Section: Acs Combinatorial Sciencementioning

confidence: 99%