Synthesis of 3,4-dihydropyrimido[1,2-a]benzimidazoles, promising CRF1 receptor antagonists

Vandyshev, D. Yu.; Kovygin, Yu. A.; Khmelevskaya, T. N.; Sherbakov, K. A.; Shikhalieva, K. D.; Smoliannikova, M. Yu.; Shikhaliev, Kh. S.

doi:10.1007/s11172-024-4213-y

Russ Chem Bull

2024

DOI: 10.1007/s11172-024-4213-y

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Synthesis of 3,4-dihydropyrimido[1,2-a]benzimidazoles, promising CRF1 receptor antagonists

D. Yu. Vandyshev,

Yu. A. Kovygin,

T. N. Khmelevskaya

et al.

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2024

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Cited by 2 publications

References 39 publications

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Design, synthesis and antitumor activity evaluation of benzimidazole derivatives with potent HDAC inhibitory activity

Ping,

Chu,

Zhao

et al. 2024

Med Chem Res

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Design, synthesis and antitumor activity evaluation of benzimidazole derivatives with potent HDAC inhibitory activity

Ping,

Chu,

Zhao

et al. 2024

Med Chem Res

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Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

Vandyshev,

Mangusheva,

Shikhaliev

et al. 2024

Beilstein J. Org. Chem.

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The heterocyclic core of imidazo[1,2-a]pyrimidine was formed in satisfactory yields as a result of the interaction of the readily available 2-aminoimidazole with N-substituted maleimides or N-arylitaconimides. The mechanism of the studied processes was postulated basing on experimental data, HPLC–MS analysis of reaction mixtures, and quantum chemical calculations. Molecular docking results of the obtained imidazo[1,2-a]pyrimidines, when compared with voriconazole, a drug already in clinical use, suggest that they may possess antifungal activity against Candida albicans.

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Synthesis of 3,4-dihydropyrimido[1,2-a]benzimidazoles, promising CRF1 receptor antagonists

Cited by 2 publications

References 39 publications

Design, synthesis and antitumor activity evaluation of benzimidazole derivatives with potent HDAC inhibitory activity

Design, synthesis and antitumor activity evaluation of benzimidazole derivatives with potent HDAC inhibitory activity

Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

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