Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I₂-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines

Abstract

Employing molecular iodine as the sole oxidant, a new and transition metal-free diamination reaction of α,β-unsaturated ketones with 2-aminopyridines has been developed. It can not only produce 3-acyl imidazo[1,2-a]pyridines but can also generate novel 2-acyl derivatives regioselectively by changing the solvent and substituents in the 2-aminopyridine substrates.

Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-a]pyridine derivatives against MARK4 protein

“…These compounds were synthesized following the previous literature. 34 Their structural analyses were determined by the spectral data like nuclear magnetic resonance ( 1 H & 13 C-NMR), single crystal as well as FT-IR spectroscopy. The synthesis of imidazo[1,2- a ]pyridine derivatives is described using various substituted chalcones containing a phenothiazine group.…”