Synthesis of 3-alkyl-4-aminofurazans

Abstract

A "one pot" method for the synthesis of 3 alkyl 4 aminofurazans from ethyl β alkyl β oxopropionates was developed. The multistep process involves hydrolysis of the ester, nitrosation at the activated methylene group, and treatment of the resulting intermediate with an alkaline solution of hydroxylamine in the presence of urea.

Reactions of 3-amino-4-methylfurazan with nitrating agents

“…The initial compound 1 19 and the authentic samples of prod ucts 2, 12 5, 35 6, 23 7, 23 8, 23 9, 37 and 11 27 were prepared by known procedures. Characteristics of the products corresponded to those published previously.…”

“…To continue the research into the reaction of furazan derivatives with nitrating reagents, we studied the nitra tion of 3 amino 4 methylfurazan 1 19 as the simplest and the most readily available model compound.…”

Ionic Liquids as Unique Solvents in One‐Pot Synthesis of 4‐(N,2,2,2‐Tetranitroethylamino)‐3‐R‐Furazans

“…A role of the N,2,2,2-tetranitroethylamino group for stabilization of the high-density crystalpacking motif is described. The performance calculations gave detonation pressures and velocities for the furazan derivatives in a range of about [31][32][33][34][35][36] GPa and 8330-8745 ms À1 , respectively, which makes them competitive energetic materials. Furthermore, due to the positive oxygen balance, the compounds could be potential oxidizers for energetic formulations.…”

A field‐based disparity analysis of new 1,2,5‐oxadiazole derivatives endowed with antiproliferative activity

“…Key intermediates 31a and 31b–g were synthesized by a one pot reaction or following a multistep procedure, respectively.…”