Synthesis of 3‐Alkylcarbonyloxymethyl Derivatives of 5‐Fluorouracil.

Abstract

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A Novel Electrosynthetic System for Anodic Substitution Reactions by Using Parallel Laminar Flow in a Microflow Reactor

“…The female hairless mice (SKH‐hr‐1) were from Charles River. The 3‐ACOM‐5‐FU prodrugs ( 2 – 7 , Figure 1) were synthesized as previously described and were identical with the literature prodrugs by 1 H‐NMR, TLC and m.p 5…”

“…In a recent article a convenient, reproducible synthesis of the 3‐ACOM‐5‐FU prodrugs has been reported,5 which makes the members of the series available for further characterization and evaluation. In this article the physicochemical properties (solubilities in isopropyl myristate and estimated solubilities in pH 4.0 buffer, S IPM and S AQ , respectively) of the C1 to C7 members of the 3‐ACOM‐5‐FU series (acetyl‐ to octanoyloxymethyl‐5‐FU, 2 – 7 ) and their abilities to deliver total 5‐FU species into and through hairless mouse skin from IPM are reported.…”

Topical delivery of 5-fluorouracil (5-FU) by 3-alkylcarbonyloxymethyl-5-FU prodrugs

“…In the determination of the solubilities in IPM, the residues from the filtrations were washed with pentane, air dried, and analyzed by m.p. and 1 H‐NMR spectroscopy 5…”

Key Dating Features for Timber-Framed Dwellings in Surrey

“…It is more common in Hampshire where nearly all the dated examples are in the 1440s, a slightly earlier range. 22 This could be another example of Hampshire fashions drifting across the border.…”