Synthesis of 3-azaharman and other new azacarbolines of the pyridazino[4,5-b]indole type

El‐Kashef, Hussein; Farghaly, Abdel-Rahman Ali Hassan; Floriani, Stephan; Haider, N.

doi:10.3998/ark.5550190.0004.e19

Cited by 2 publications

(1 citation statement)

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“…From 2-acetylindole-3-carboxylic acid. Haider et al 44 had done a modification on the procedure of preparation of pyridazino [4,5-b]indole 107 which was reported previously by Zhungietu et al 45 by condensation of 2-acetylindole-3-carboxylic acid 105 with hydrazine hydrate at elevated temperature. This reaction, however, suffers from poorly reproducible yields which reflect the high decarboxylation tendency of the starting material, causing a significant side reaction (formation of 2-acetylindole or its hydrazone, respectively).…”

Section: From 2-indolecarbohydrazidesmentioning

confidence: 99%

Synthetic strategies of pyridazino[4,5-b]indoles

Farghaly¹

2023

Arkivoc

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Pyridazino [4,5-b]indole is an important class of heterocyclic compounds with numerous applications in the field of medicinal chemistry. This review summarizes the synthetic methods of pyridazino [4,5-b]indoles published during the period from 1962 to 2022. In this review, we have discussed different methods for the synthesis of pyridazino [4,5-b]indole from various starting materials and the difficulties that scientists faced during the preparation process. We focus on the recent developments in synthetic methods of the pyridazino [4,5-b]indoles. Pyridazino[4,5-b]indoles Biological importance of pyridazino[4,5-b]indoles ✓ As anxiolytic ✓ As antihypertensive ✓ As thromboxane A2 synthetase inhibitors ✓ As antihistaminic ✓ As HIV-1 reverse transcriptase inhibitors ✓ As antiarrhythmics ✓ As phosphatidylinositol 3-kinase (PI3K) inhibitors ✓ As blood platelet aggregation inhibitors

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Section: From 2-indolecarbohydrazidesmentioning

confidence: 99%