Synthesis of 3-deazaneplanocin A analogs and their antiviral activity against RNA-viruses

Choi, Se Myeong; An, Yeon Jin; Choi, Eun Rang; Nam, Ye Eun; Seo, Eun Woo; Kang, Changhyun; Ahn, Soo Bin; Kim, Uk-Il; Kim, Meehyein; Kim, Kyungjin; Cho, Jong Hyun

doi:10.1016/j.molstruc.2022.134775

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2022.134775

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Synthesis of 3-deazaneplanocin A analogs and their antiviral activity against RNA-viruses

Se Myeong Choi

Yeon Jin An

Eun Rang Choi

et al.

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2024

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3-Deazaneplanocin A (DZNep): A Drug That Deserves a Second Look

Marquez

2024

J. Med. Chem.

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The emerging data compiled during the past five years on 3-deazaneplanocin (DZNep) provide compelling evidence to reevaluate this drug as a better alternative over the specific catalytic inhibitors of histone methyl transferases (HTMs). The indirect mechanism of DZNep via inhibition of AdoHcy-ase, once considered a liability due to possible side effects, has now shown to be rather beneficial as additional pathways targeted by DZNep are important contributors to its superior anticancer properties. Furthermore, DZNep has demonstrated the ability to induce proteasomal degradation of its target and reduce toxicity in combination with well-established antitumor therapies in animal models. In addition, DZNep has shown important effects in suppressing fibrosis and inflammation in liver, kidney, peritoneum, and airways. Finally, inhibition of mRNA m 6 A methylation by DZNep suppresses the synthesis of the viral genome in SARS-Cov-2 infection and promises to have important therapeutic value when combined with its potent antiviral efficacy and anti-inflammatory effects.

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3-Deazaneplanocin A (DZNep): A Drug That Deserves a Second Look

Marquez

2024

J. Med. Chem.

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Synthesis of 3-deazaneplanocin A analogs and their antiviral activity against RNA-viruses

Cited by 1 publication

References 28 publications

3-Deazaneplanocin A (DZNep): A Drug That Deserves a Second Look

3-Deazaneplanocin A (DZNep): A Drug That Deserves a Second Look

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