Synthesis of 3′-deoxy-3′-fluorothymidine (FLT) 5′-O-glucuronide: a reference standard for imaging studies with [¹⁸F]FLT

Abstract

The de novo synthesis of 3′-deoxy-3′-fluorothymidine-5′-O-glucuronide enabled both the analysis of this reference standard by HPLC and identification of the metabolite in a blood sample from a patient administered [18F]FLT.