Synthesis of 3β,6α-dihydroxy-5α-cholan-23-one

Synthesis of hydroxy acids of dinorcholane and 5β-cholane

“…However, if a chiral centre already exists next to the carbonyl carbon, two possible diastereomeric products are formed, and they are not of equal amounts. As part of our on-going studies on the synthesis and reactions of steroid monomers and dimers, [2][3][4][5][6][7][8] we now report on the development of a convenient and general method for the synthesis of diasteriomerc (55:45) dinorcholane hydroxy acids and 5β-cholane hydroxy acid using readily available dinorcholanal and 5β-cholane-3α,24-diol as the starting materials.…”

X-ray crystal structure of 3β,22-dihydroxy-23,24-dinorchol-4-ene

“…The title compound (I) was synthesised as part of a study on 23-oxocholestane conjugates. 1 We undertook an X-ray crystallographic analysis to confirm the molecular structure and to establish the crystal structure. Of particular interest was the potential hydrogen bonding between hydroxy groups at positions 3 and 22.…”

Synthesis of Pregnenolone and Methyl Lithocholate Oxalate Derivatives

“…The fact that small changes in the functionalities attached to the steroid skeleton can cause marked changes in their biological activity has prompted synthetic chemists to carry out structural modifications of steroids [1,2]. As part of our on-going studies on the synthesis of various steroidal derivatives [3][4][5][6][7][8], we report on the synthesis of five new pregnenolone and methyl lithocholate oxalate derivatives that contain an oxalate ester linkage at C-3 of the steroid molecules.…”

“…6 . The IR spectrum showed absorption bands at 1765 and 1739 cm -1 for oxalate ester functionalities.…”