Synthesis of [3β-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823

Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer

“…It triggers the death of BGC-823 cells by inducing apoptosis via the mitochondria pathway involving the caspasesdependent apoptotic mechanism (Bai et al, 2011). Progression of cell cycle is tightly controlled by the action of various classes of cyclins and cyclin-dependent protein kinases (CDKs).…”

Enhancement of Radiation Effects by Ursolic Acid in BGC-823 Human Adenocarcinoma Gastric Cancer Cell Line

“…At this dose, UA had slight cytotoxicity to human adenocarcinoma gastric cancer cell line BGC823 and did not have significant cytotoxicity to normal gastric cell line. [ 17 ] This demonstrated that UA was a promising radiosensitization in vitro .…”

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

“…The ursolic acid derivatives in Group II exhibited potent cytotoxicity, with enhancement of the lipophilicity further strengthening cytotoxicity [68]. The same group of researchers also synthesized another ursolic acid derivative, 3b-acetoxy-urs-12-en-28-oyl-1-monoglyceride that was found to trigger the death of BGC-823 cells by inducing apoptosis via the mitochondria pathway [69]. Ursolic acid derivative, N-[3b-acetoxy-urs-12-en-28-oyl]-2-aminodiethanol, was tested with increasing concentrations of test compound for 24 h. Dose-dependent induction of apoptosis was observed in various tumor cell lines including, HepG2, BGC-823, SH-SY5Y, HeLa, and HELF [70].…”