Synthesis of 4‐(1‐Phenylmethyl‐5‐imidazolyl)‐1,4‐dihydropyridines as Calcium Channel Antagonists.

Hadizadeh, Fatemeh; Shafiee, Abbas; Kazemi, Reihaneh; Mohammadi, Mohammadjavad

doi:10.1002/chin.200313145

Cited by 8 publications

(8 citation statements)

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“…We reported that 1,4-dihydropyridine derivatives 1a–h using the Hantzsch method (Hadizadeh et al, 2002). Compounds 2a–h, 3a–e, and 4a–e were prepared via amination method (Scheme 1).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives

Ahamed

Arif

Mateen

et al. 2018

Saudi Journal of Biological Sciences

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A new series of 1,4-dihydropyridine derivatives ( and were systematically designed and synthesized via ultrasound irradiation methods with easy work-up and good yields. Compounds structures were confirmed by IR,H NMR, C NMR, and mass spectra. The synthesized compounds were screened for both antimicrobial and anticoagulant activities. Compound (MIC: 0.25 μg/mL) was highly active against and compound (MIC: 0.5 μg/mL) was also highly active against compared with ciprofloxacin. (MIC: 1 μg/mL) The antifungal activity of (MIC: 0.5 μg/mL) against was high relative to that of clotrimazole (MIC: 1 μg/mL). Anticoagulant activity was determined by activated partial thromboplastin time (APTT) and prothrombin time (PT) coagulation assays. Compound 4-(4-hydroxyphenyl)-2,6-dimethyl-,-bis(5-phenyl-1,3,4-thiadiazol-2-yl)-1,4-dihydropyridine-3,5-dicarboxamide (>1000 s in APTT assays) was highly active in anticoagulant screening compared with the reference of heparin. Cytotoxicity was evaluated using HepG2 (liver), HeLa (cervical), and MCF-7 (breast) cancer cell lines, with high toxicities observed for (GI = 0.02 μm) against HeLa cell line and (GI = 0.03 μm) equipotant against MCF-7 cell line. Therefore, the compounds and can serve as lead molecules for the development of new classes of antimicrobial and anticoagulant agent.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives

Ahamed

Arif

Mateen

et al. 2018

Saudi Journal of Biological Sciences

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“…2,6-dimethyl-4-substitutedphenyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give 2,2’-{[4-(4-substituted aromatic alcohols)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothio amide (2a-g) by hydrazinolysis method[2425] (Scheme 1). The Physical constants and percentage yields of all compounds are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives

Kumar¹,

Idhayadhulla²,

Nasser³

et al. 2010

Indian J Pharm Sci

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A series of 1,4-dihydropyridine derivatives (1a–g) were prepared from three compounds condensation of Hantzsch synthesis. A new series of 2,2’-{[4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbothioamide (2a-g) were prepared from compounds diethyl 4-(aryl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1a-g) reacted with thiosemicarbazide to give the corresponding compounds (2a-g) by hydrazinolysis method. The synthesized compounds were confirmed by IR, 1HNMR, 13CNMR, mass spectral and elemental analyses. The newly synthesized compounds (2a-g) were screened for anticonvulsant activity against in swiss albino rat. The test was evaluated by maximal electrode induced convulsion method. Synthesized compounds were used two (50 and 100 mg/kg) concentrations. Compounds (1a-g) were inactive while compounds (2a-g) have moderate anti-convulsant activity compared with standard phenytoin drug. The compound 2,2’-{[4-(furan-2-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl} dihydrazinecarbothioamide (2a) has highly active compared with other compound (2b-2g).

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“…A series of diethyl 2,6-dimethyl-(4-substitutedphenyl)-1,4-dihydropyridine-3,5-dicarboxylate derivatives (1aeg) were prepared as base compounds by following the method previously described in the literature [24]. The 2,6-dimethyl-4-substituted phenyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives (1aeg) were reacted with thiosemicarbazide to give 2,2 0 -{[4-(4-substitutedphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl]dicarbonyl}dihydrazinecarbot-hioamide compounds (2aeg), shown in Scheme 1.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives

Kumar¹,

Idhayadhulla²,

Nasser³

et al. 2011

European Journal of Medicinal Chemistry

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Synthesis of 4‐(1‐Phenylmethyl‐5‐imidazolyl)‐1,4‐dihydropyridines as Calcium Channel Antagonists.

Cited by 8 publications

References 0 publications

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives

Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives

Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives

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