Synthesis of 4-[18F]Fluorophenyl-alkenes and -arenes via Palladium-Catalyzed Coupling of 4-[18F]Fluoroiodobenzene with Vinyl and Aryl Tin Reagents.

Comparison of pathways to the versatile synthon of no‐carrier‐added 1‐bromo‐4‐[18F]fluorobenzene

“…The decision for one of the purification procedures is depending on the desired following reaction. For Pd-catalyzed reactions, like Stille 13 or Sonogashira 15 coupling or for the magnesium-or lithium reactions 12 it is not necessary to remove the iodobenzenes formed by the decomposition of the iodonium salt. Here, a simple purification procedure via a silica gel cartridge is probably the easiest way to remove the solvent DMF, the phase 18 F]fluorobenzene 1 in high radiochemical and chemical purity, a GCprocedure appears the best way for purification, but it is hard to automate and leads to a lower yield which is due to more purification steps (see experimental part).…”

“…[13][14][15] The aim of this study was to examine different methods for a facile, one-pot synthesis of 1-bromo-4-[…”

No‐carrier added synthesis of 18F‐labelled nucleosides using Stille cross‐coupling reactions with 4‐[18F]fluoroiodobenzene

“…A combination of a 1:1:1 molar ratio of Pd 2 (dba) 3 /CuI/AsPh 3 gave the highest radiochemical yield of 69% (entry 10). The combination Pd 2 (dba) 3 19 F-NMR spectra were recorded on a Varian Inova-400 at 400 and 376 MHz, respectively. Chemical shifts (d) are determined relative to the solvent and converted to the TMS scale.…”

Application of n.c.a. 4‐[18F]fluorophenol in diaryl ether syntheses of 2‐(4‐[18F]fluorophenoxy)‐benzylamines

“…24 Colourless oils were obtained and yields were 89 and 80%, respectively. 2-(4-Fluorophenoxy)-N-methylbenzylamine (5) and 2-(4-fluorophenoxy)-N,Ndimethylbenzylamine (6). Two millimoles of 3 and 4, respectively, were dissolved in 10 ml water free THF and cooled to 08C.…”

“…Several no-carrier-added 18 4 and palladium-mediated coupling reactions. [5][6][7] Also, the 4-[ 18 F]fluorophenoxy moiety lends itself to potentially extending the variety of radiotracers and radioligands for PET. It was for example recently shown, that 4-[…”