Synthesis of 4-aryl-1,2,3-triazolyl appended natural coumarin-related compounds with antiproliferative and radical scavenging activities and intracellular ROS production modification

Abstract

Diverse natural coumarin-based compounds linked to aryl via a 1,2,3-triazole spacer with antiproliferative activity against K562 cells, radical scavenging activity and a decrease of ROS production were provided.

Quinoline and ferrocene conjugates: Synthesis, computational study and biological evaluations

“…The antiradical activity of the tested compounds was determined according to the described procedure . Briefly, a 0.1 mM DPPH radical solution in 95% methanol was prepared, and 0.5 ml of this solution was mixed with 0.5 ml of compounds 16a – e , 17a – e , 18a – e , 19a – d , 20a – d , and reference compounds umbelliferon (7‐hydroxycoumarin) and esculetin (6,7‐dihydroxycoumarin) in 0.2 mM concentrations.…”

Cross-dehydrogenative coupling of coumarins with Csp3–H bonds using an iron–organic framework as a productive heterogeneous catalyst

“…7a). Next, several MOF-based catalysts were explored for this reaction, including VNU-20, Fe 3 O(BDC) 3 2 (DABCO) as catalysts led to higher initial rates. However, 81% and 82% yields were obtained for the reaction aer 6 h. The transformation using the VNU-20 catalyst proceeded with lower initial rate in the rst 4 h reaction time.…”

“…[1][2][3][4] The functionalization of naturally occurring skeletons has gained signicant attention, as interesting and unexpected biological properties would be generated. [5][6][7] Among several synthetic strategies, reactions via direct C-H bond activation have exhibited signicant advantages, avoiding the preparation of prefunctionalized reactants and the purication of intermediate products.…”

“…Niu et al previously performed the direct couplings of coumarins with cyclic ethers using a FeCl 3 catalyst. 11 Wang et al synthesized a variety of C-3 functionalized coumarins via the Cu(OAc) 2 catalyzed reaction with cyclic ethers and cycloalkanes. 12 Cao et al developed a novel approach for the direct Csp 2 -H radical triuoromethylation of coumarins in the presence of Mn(OAc) 3 .…”

“…14 Cheng et al prepared several biologically active coumarin derivatives via Pd(OAc) 2 -catalyzed intramolecular cross-dehydrogenative coupling reaction. 15 For more environmentally benign synthetic strategies, transformations of coumarins utilizing heterogeneous catalysts should be explored to achieve simple workup, recyclability, and reusability.…”