Synthesis of 4-Aryl-3,4,5,6-Tetrahydropyrimido[5,4-g]Indolizine-2(1H)-Thione

Abstract

A number of 4-aryl-3,4,5,6-tetrahydropyrimido[5,4-g]indolizine-2(1H)-thiones were synthesised by the reaction of (7E)-7-arylidene-6,7-dihydroindolizin-8(5H)-one and thiourea in the presence of potassium hydroxide in moderate yields. The structures of all the products were characterised thoroughly by NMR, IR and HRMS together with X-ray crystallographic analysis.

KI-catalyzed synthesis of S-Thiocarbamates by cross-coupling of cyclohexyl isocyanide with sulfonyl chlorides

“…In the past few decades, the synthesis and study of organic sulfur chemicals has become a popular research topic. [1][2][3][4][5][6] S-Thiocarbamates represent key building blocks that are common in many synthetic pharmaceuticals and natural biologically active compounds. 7 They have numerous biological applications in the manufacture of pharmaceuticals and agrochemicals including the HIV-1 nucleocapsid protein NCp7 inhibitor 8 and bactericidal, 9 anesthetic, 10 fungicidal, 11 pesticidal, 12 and herbicidal 13 substances.…”