Synthesis of 4‐Arylpyridines Containing Electron‐Withdrawing Groups on the Benzene Ring

Abstract

4‐Arylpyridines 5 that contain electron‐withdrawing groups such as nitrile, methyl ester, fluoride, and trifluoromethyl on the benzene ring were synthesized in moderate yields (29‐63%) by reaction of mixed copper, zinc aryl organometallics 1 with various 1‐(ethoxycarbonyi)pyridinium chlorides 2 followed by o‐chloranil oxidization under reflux in toluene.