Synthesis of 4-trifluoromethyl pyridazines via annulation of pyridinium ylides with trifluoroacetyl diazoester

Abstract

A base promoted annulation of pyridinium ylides with trifluoroacetyl diazoester has been reported. Highly functionalized 4-trifluoromethyl pyridazines were synthesized in good yields without the use of any heavy metal catalysts....

Recent advances in versatile pyridazine-cored materials: principles, applications, and challenges

“…This review calls for more efforts to enrich versatile PDs for high-performance materials beyond bioactive pharmaceutical drugs and pesticides. 49,147 For the sake of more and better functional PD-ringbased materials, herein, the general strategy can be explored by combining the previous studies and interesting results with practical synthetic methodologies (Scheme 7), 50,106,[148][149][150][151][152][153][154][155][156] theoretical calculations, 129,[157][158][159][160][161] aza-quantity effect and azaregioisomerism, 159,160 and supramolecular strategies, 29,[162][163][164][165] the serendipitously discovered or well-designed of PD-based materials possess huge application prospects in the fields of optoelectronics, chromism, fluorescence probes, and energy materials. The unceasing breakthroughs in catalysis, 9,45,115,154,166,167 magnetic complexes, 155,168 molecular rotators (Fig.…”

Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates

“…In the same year, the annulation of pyridinium bromides 34a , b with trifluoroacetyl diazoester 35 was reported as a useful method for the formation of 4‐trifluoromethyl pyridazine derivatives 36a , b (Scheme 16) (Fang et al, 2022).…”

Zirconium-Catalyzed Synthesis of 6-(Trifluoromethyl)-2H-pyran-2-ones via C–C Bond Cleavage

“…Our research group has been interested in the utilization of CF 3 -containing building blocks for the preparation of many important trifluoromethylated heterocycles including 4-trifluoromethylpyrazoles, 2-trifluoroethyl benzofurans, 5-aryl-6-(trifluoromethyl)-2,3-dihydropyrazolo­[1,2- a ]­pyrazol-1­(5 H )-ones, 2-trifluoromethyl pyrroles, 4-trifluoromethyl pyridazines, and 2-trifluoromethyl benzimidazole derivatives . On the other hand, alkynones serve as versatile synthons in several transformations to provide various synthetically useful heterocycles .…”