Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives

Abstract

Earlier unknown 4 alkoxy and 4 hydroxy 5 methyl 4 trifluoromethyl 1,4 dihydropyri do[4,3 d]pyrimidines were obtained by the reaction of 5 acetyl 4 dimethylaminovinyl 6 (trifluoromethyl)pyrimidine with alcoholic (aqueous) solutions of NH 3 . The former eliminate alcohol (water) on sublimation in vacuo to be converted to 5 methyl 4 (trifluoromethyl) pyrido[4,3 d]pyrimidine. The latter upon the action of alcohols (water) under mild conditions were reverted to the corresponding 4 alkoxy and 4 hydroxydihydropyrido[4,3 d]pyrimidines.