Synthesis of 4H-cyclopenta[c]furan-5(6H)-one derivatives

Highly Diastereoselective Synthesis and Application of Functionalized 2,3-Dihydrofuran Derivatives from Enynones and Bis(diazo) Compounds

“…Finally, this synthetic application of the functionalized 2,3-dihydrofuran derivatives 3 has been preliminarily investigated based on the transformation of the diazo group and the CC triple bond, as shown in Table . In pathway A, the first conversion of 3aa to 10aa was examined.…”

Silver(I)-Catalyzed Tandem Reaction of Enynones and 4-Alkenyl Isoxazoles: Synthesis of 2-(Furan-2-yl)-1,2-dihydropyridines

“…1,2-Dihydropyridine and furan scaffolds are widely present in bioactive molecules and natural products and have also been widely applied as a synthetic block. − Therefore, 1,2-dihydropyridine bearing a furyl group at 2-position (i.e., 2-furyl-1,2-dihydropyridine), which is a novel linked bis-heterocyclics, is an important structural skeleton based on potential among biological activities and synthetic applications. Many exciting achievements on the individual construction of 1,2-dihydropyridine and furan , framework have been made; however, these methodologies involved are usually non-atom-economic routes.…”

Controllable Access to Diazo-functionalized 2-Methylene-2,3-dihydrofurans and Diazo-functionalized Furans from Enynones and Diazo Carbonyl Compounds

“…Few methods for their preparation and synthetic application have been disclosed. For instance, the synthesis of naphthalene [1,2- b ] furans via C–H insertion of furan containing a diazo group (Scheme c) and the construction of penta-substituted aromatic compounds via cyclopropanation/rearrangement/isomerization of diazo 2,3,5-trisubstituted furans have been developed (Scheme d) . Overall, investigation of their synthesis and application is lacking, and it has become a considerable challenge.…”