Synthesis of 5-Fluoro Salicylic Acid

Sharma, G. V. M.; Ilangovan, A.; Lavanya, B.

doi:10.1080/00397910008087335

Search citation statements

Order By: Relevance

Paper Sections

Select...

Materials and Measurements1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2000

2014

Publication Types

Select...

Article4

Book1

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reagents used in the synthesis were obtained from Aldrich and were of analytical grade. Compounds 1, 2, 10, and 12 were synthesized according to the literature methods [28][29][30][31][32] .…”

Section: Materials and Measurementsmentioning

confidence: 99%

Synthesis and in vitro evaluation of new diphenyl ether derivatives as serotonin transporter ligands

Guo

Chen

Jia

et al. 2008

Sci. China Ser. B-Chem.

View full text Add to dashboard Cite

For the development of new ligands as potential imaging agents for the serotonin transporter (SERT), a series of diphenyl ether derivatives have been synthesized, characterized, and evaluated for their in vitro binding affinities to the SERT. Among the above compounds, 2-(2-((dimethylamino)methyl)-4-fluorophenoxy)-5-bromobenzenamine (15) and 2-(2-((dimethylamino)methyl)-4-fluorophenoxy)-5-iodobenzene amine (16) show high binding affinities for the SERT with K i values of 0.28 and 0.20 nmol·L 1 , respectively. They can be further labeled with carbon-11, fluorine-18, iodine-123 or bromine-76, and evaluated as useful imaging agents for the SERT. Moreover, the study of the structure-activity relationship (SAR) provides some useful information for the future design of new ligands. serotonin transporter, diphenyl ether, imaging agents, in vitro evaluation

show abstract