Synthesis of 5
H
-Pyrrolo[3,4-
b
]Pyridin-5-Ones
via
a Cerium Chloride Catalyzed Multicomponent Cascade Process: A One-Pot Approach Incorporating Ugi-Zhu 3CR, Aza Diels–Alder,
N
-Acylation, and Aromatization Reactions
Ramasamy Duraisamy,
M. B. Madhusudana Reddy,
I. V. Asharani
et al.
Abstract:Experimental procedure and complete spectral data of the final products Experimental:
Synthesis of 2-isocyano-1-morpholinoethanone (c)A mixture containing ethyl 2-isocyanoacetate (10 g, 88.4 mmol), methanol (50 mL), and morpholine (10 g, 114.7 mmol) was stirred at 25 °C for 16 h. After completion of the reaction, as indicated by TLC, the reaction mixture was concentrated to dryness, and the crude was absorbed on silica gel and purified by column using chloroform: methanol.
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