Synthesis of 5‐methylthioribose specifically bitritiated at the 5‐C position

Abstract

SummaryAn efficient and reliable method for the preparation of bitritiated-methylthioribose from a suitably protected 5-ketoazido-ribose derivative has been developed. This compound is an essential component in the assay of the microbial enzyme methylthioribose kinase, which is involved in the methionine salvage pathway from methylthioadenosine.