Synthesis of 5-substituted 1H-tetrazoles Using Natural and Reusable Natrolite Zeolite

Sajadi, S. Mohammad; Mahamb, Mehdi

doi:10.2174/157017861101140113160634

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…The catalyst is also simple to make, non-toxic, and ecologically benign, all of which satisfy the green chemistry guidelines and could be a promising alternative for broad application in organic synthesis. 5-substituted-1H-tetrazole derivatives 66%-82% were also synthesized in the presence of natrolite zeolite as a catalyst (Scheme 9) in another study (Sajadi & Maham, 2014). Natrolite zeolites are very efficient, eco-friendly, and can be reused numerous times without losing their activity.…”

Section: S C H E M Ementioning

confidence: 99%

Tetrazole: A privileged scaffold for the discovery of anticancer agents

et al. 2022

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Carcinoma, characterized by abnormal growth of cells and tissue, is a ubiquitously leading cause of mortality across the globe due to some carcinogenic factors. Currently, several anticancer agents are commercially available in the global market. However, due to their resistance and cost, researchers are gaining more interest in developing newer novel potential anticancer agents. In the search for new drugs for clinical use, the tetrazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules. Among the various heterocyclic agents, tetrazole-containing compounds have shown significant promise in the treatment of a wide range of diseases, particularly cancer. Here, in this review, we focused on several synthetic approaches for the synthesis of tetrazole analogs, their targets for treating cancer along with the biological activity of some of the recently reported tetrazole-containing anticancer agents.

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Section: S C H E M Ementioning

confidence: 99%