Synthesis of 6‐arylazo‐substituted 5‐hydroxy‐2‐hydroxymethyl‐4‐pyridones and related compounds

Abstract

5‐Hydroxy‐2‐hydroxymethyl‐4‐pyridone (1) and 5‐hydroxy‐2‐hydroxymethyl‐1‐methyl‐4‐pyridone (2) reacted with arenediazonium salts to give 6‐arylazo‐substituted compounds 3a‐d and 4a‐d, respectively. Compounds 3a‐d were methylated with diazomethane to afford 6‐arylazo‐2‐hydroxymethyl‐4,5‐dimethoxypyridines 5a‐d.

Kojic acid in organic synthesis

“…Treatment of KA with thionyl chloride in DMF at room temperature, followed by reaction with potassium salts of benzoic acids in DMF at [110][111][112][113][114][115][116][117][118][119][120] • C, gave benzoate derivatives 269 in good yields.…”