Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity

Ziyadullaev, Mirjalol; Karimov, Rikhsiboy; Abdurazakhov, Asqar; Parmanov, Asqar; Sasmakov, Sobirdjan; Abdurakhmanov, Jaloliddin; Eshboev, Farkhod; Azimova, Shakhnoz

doi:10.1007/s11094-023-02892-3

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…This reduces the available treatment options for patients and can lead to increased morbidity and mortality rates. Furthermore, the development of new drugs to combat AMR has been relatively slow, leading to a limited number of novel drugs in the pharmaceutical pipeline [ 99 , 100 ].…”

Section: Effects Of Natural Compounds Obtained From Endophytes On Ant...mentioning

confidence: 99%

“…Multiple mechanisms of resistance to antibacterial drugs have been discovered by bacteria, including drug inactivation, modification of the antibiotic’s targets in bacteria, reduced intracellular drug accumulation due to decreased permeability and antibiotic efflux, formation of biofilms, overexpression of molecular targets that are affected by antibiotics, and utilization of alternative metabolic pathways [ 100 , 104 , 105 ].…”

Section: Effects Of Natural Compounds Obtained From Endophytes On Ant...mentioning

confidence: 99%

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Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Eshboev,

Mamadalieva,

Nazarov

et al. 2024

Antibiotics

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Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous new antimicrobial compounds have been isolated from endophytes, particularly from endophytic fungi and actinomycetes. However, only a limited number of these compounds have been subjected to comprehensive studies regarding their mechanisms of action against bacterial cells. Furthermore, the investigation of their effects on antibiotic-resistant bacteria and the identification of biosynthetic gene clusters responsible for synthesizing these secondary metabolites have been conducted for only a subset of these promising compounds. Through a comprehensive analysis of current research findings, this review describes the mechanisms of action of antimicrobial drugs and secondary metabolites isolated from endophytes, antibacterial activities of the natural compounds derived from endophytes against antibiotic-resistant bacteria, and biosynthetic gene clusters of endophytic fungi responsible for the synthesis of bioactive secondary metabolites.

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Section: Effects Of Natural Compounds Obtained From Endophytes On Ant...mentioning

confidence: 99%

Section: Effects Of Natural Compounds Obtained From Endophytes On Ant...mentioning

confidence: 99%

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Eshboev,

Mamadalieva,

Nazarov

et al. 2024

Antibiotics

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View full text Add to dashboard Cite

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“…The antimicrobial activity of the extracts obtained from endophytic fungal isolates derived from H. officinalis was evaluated using the agar disk-diffusion method, as described in reference [41]. The antimicrobial activity was assessed against five species of microorganisms, including Gram-positive bacteria B. subtilis and S. aureus, Gram-negative bacteria E. coli and P. aeruginosa, and the yeast C. albicans.…”

Section: Antimicrobial Activities Of Extractsmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis

Eshboev,

Karakozova,

Abdurakhmanov

et al. 2023

Antibiotics

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According to the World Health Organization, it is estimated that by 2050, drug-resistant infections could cause up to 10 million deaths annually. Therefore, finding a new generation of antibiotics is crucial. Natural compounds from endophytic fungi are considered a potential source of new-generation antibiotics. The antimicrobial and cytotoxic effects of ethyl acetate extracts of nine endophytic fungal isolates obtained from Hyssopus officinalis were investigated for bioassay-guided isolation of the natural compounds. An extract of isolate VII showed the highest antimicrobial activities against Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus (30.12 ± 0.20 mm and 35.21 ± 0.20 mm) and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa (30.41 ± 0.23 mm and 25.12 ± 0.25 mm) among the tested extracts of isolates. Molecular identification of isolate VII confirmed it as Chaetomium elatum based on sequencing of its ITS genes, and it was discovered that this was the first time C. elatum had been isolated from H. officinalis. This isolate was cultured at a large scale for the isolation and identification of the active compound. Penicillic acid was isolated for the first time from C. elatum and its chemical structure was established by NMR spectroscopy. The penicillic acid showed strong antibacterial activities against Bacillus subtilis and Staphylococcus aureus with 20.68 mm and 25.51 mm inhibition zones, respectively. In addition, MIC and MBC values and antibiofilm activities of penicillic acid were determined. It was found that penicillic acid reduced the level of biofilms in proportion to antibacterial activity.

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Soil Microbiome Bioengineering for Improvement of Soil Health and Fertility

Eshboev,

Abdurakhmanov,

Egamberdieva

et al. 2024

Progress in Soil Science

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Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity

Cited by 6 publications

References 25 publications

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Antimicrobial and Cytotoxic Activities of the Secondary Metabolites of Endophytic Fungi Isolated from the Medicinal Plant Hyssopus officinalis

Soil Microbiome Bioengineering for Improvement of Soil Health and Fertility

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