Synthesis of 7,8‐dihydroxy‐3‐(3,4‐dihydroxyphenyl)‐2H‐chromen‐2‐one derivatives of crown ethers

Abstract

C NMR, and MALDI-TOF mass spectrometry and elemental analysis.

In Vitro Inhibition of Human Placental Glutathione S‐Transferase by 3‐Arylcoumarin Derivatives

“…All other chemicals were of analytical grade and were used without further purification. 3‐Arylcoumarin derivatives were prepared by the reaction of substituted hydroxybenzaldehydes with the corresponding arylacetic acids under the traditional Perkin conditions . Scheme of synthesis of the 3‐arylcoumarin derivatives has been shown in Scheme .…”

“…Compound 5c (2.9 g, 10 mmol) was treated as described above to yield 6b (2.3 g, 79.2%). Mp 294°C (295°C in the literature ). 1 H NMR (400 MHz, DMSO): δ = 6.69 (d, J = 8.4 Hz, 1H), 6.85 (d, J = 8.4 Hz, 1H), 6.95 (dd, J = 8.4 and 2.0 Hz, 1H), 7.17 (d, J = 8.4 Hz, 1H), 7.25 (d, J = 2Hz, 1H), 7.91 (s, 1H), 9.07 (s, 1H), 9.13 (1H), 9.36 (s, 1H), and 9.91 (s,1H) ppm.…”