Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents

Synthesis and Characterization of Immobilized Lipase on Fe3O4 Nanoparticles as Nano biocatalyst for the Synthesis of Benzothiazepine and Spirobenzothiazine Chroman Derivatives

“…Benzothiazepine structure is so multifunctional that a great number of known drugs such as dithiazem, clentiazem, and thiazesim possess such structure [1]. Benzothiazines also demonstrate widespread medicinal properties such as antimicrobial [2], antimalarial [3], and anti-inflammatory medications [4].…”

(Z)-2-(2-Chlorobenzylidene)-4-(prop-2-ynyl)-2H-1,4-benzothiazin-3(4H)-one

“…The 1,4-benzothiazine ring system represents an important class of compounds, not only for their theoretical interest, but also for their analgesic (Wammack et al, 2002); anti-viral (Malagu et al, 1998;Rathore & Kumar, 2006) and anti-oxidant activities (Zia-ur-Rehman et al, 2009). Recently, related research has been focused on existing molecules and their modifications in order to reduce their side effects and to explore their other pharmacological and biological effects (Sebbar et al, 2016a;Armenise et al, 2012).…”

New Routes for the Synthesis Novel Heterocyclic via Formation of C-N Bond and via Cleavage a Thiazine Ring of Benzothiazine

“…Benzothiazines are considered to be suitable candidates for different pharmacological activities, such as anticancer [1] antiproliferative agents [2], antimicrobial [3], antifungal activity [4].In some cases 1,4-benzothiazines are also known for their utility as dyes, photographic developers, ultraviolet absorbers light and antioxidants [5]. In continuation of our interest in the synthesis of functionally substituted heterocyclic compounds [6][7][8], we report here the behavior of 2-acetyl-3-methyl-4H-benzo[b] [1,4]thiazine toward carbon and nitrogen nucleophiles in the synthesis of pyrazole, pyridine and pyrazolopyridine derivatives.…”