Synthesis of a [2]-cryptand with carbon bridgeheads

Coxon, Andrew C.; Stoddart, Fraser

doi:10.1016/s0008-6215(00)84350-5

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…Even though the coppercatalyzed click reaction is very popular, this catalyst can inhibit the protein's activity and is toxic to the host in certain doses, which is problematic when the reaction is carried out in vivo [117]. In spite of this, the rapid development of click reactions is evident from its use in a variety of disciplines, including medicinal chemistry, materials and polymer science due to its great advantages, such as its high nanoparticle-tobiomolecule coupling performance [103,118].…”

Section: Peptide-nanoparticle Interactionsmentioning

confidence: 99%

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Arias-Arana¹,

Palomino-Marcelo²,

Gakiya-Teruya³

et al. 2022

Nano BioMed ENG

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Section: Peptide-nanoparticle Interactionsmentioning

confidence: 99%

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Arias-Arana¹,

Palomino-Marcelo²,

Gakiya-Teruya³

et al. 2022

Nano BioMed ENG

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Rapid Screening of Binding Constants by Calibrated Competitive ¹H NMR Spectroscopy

Heath

Dykes

Fish

et al. 2003

Chemistry A European J

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A calibrated competitive NMR method has been developed that is appropriate for the rapid screening of binding constants. This method involves the initial characterisation of a receptor-substrate binding event for which the (1)H NMR spectrum of a given receptor (calibrant) is modified by the substrate of interest at a range of concentrations. For all subsequent "unknown" receptors, K(a) values are then determined by using a competition assay (in the presence of the calibrant receptor) by measuring a single standard (1)H NMR spectrum. This enables a rapid assessment of the recognition properties of a library of potential receptors. Only the calibrant receptor needs to be NMR active, while the library of putative receptors, as well as the substrate, can be NMR silent. This method assumes the formation of complexes of 1:1 stoichiometry. To demonstrate this methodology, the binding of a number of crown ether type compounds with K+ ions has been studied. Comparison of the binding strengths obtained by using this approach with those in the literature shows excellent agreement. A range of new compounds that have recently been synthesised within our group has also been screened in order to illustrate how this approach can rapidly assess binding ability. This method has significance for chemists working in the fields of combinatorial receptor/substrate design and supramolecular chemistry as a means of rapid optimisation of binding strength.

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Synthesis of new chiral macrocycles-based glycolipids and its application in asymmetric Michael addition

2021

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Synthesis of a [2]-cryptand with carbon bridgeheads

Cited by 6 publications

References 9 publications

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Rapid Screening of Binding Constants by Calibrated Competitive ¹H NMR Spectroscopy

Synthesis of new chiral macrocycles-based glycolipids and its application in asymmetric Michael addition

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Synthesis of a [2]-cryptand with carbon bridgeheads

Cited by 6 publications

References 9 publications

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Nanoparticles as Carriers in Medical Applications: A Review Focusing on the Preparation and Use of Nanoparticles in Tissue Regeneration

Rapid Screening of Binding Constants by Calibrated Competitive 1H NMR Spectroscopy

Synthesis of new chiral macrocycles-based glycolipids and its application in asymmetric Michael addition

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Rapid Screening of Binding Constants by Calibrated Competitive ¹H NMR Spectroscopy