Synthesis of a biocompatible benzophenone-substituted chitosan hydrogel as novel coating for PEEK with extraordinary strong antibacterial and anti-biofilm properties

Borgolte, Max; Riester, Oliver; Quint, Isabel; Blendinger, Felix; Bucher, Volker; Laufer, Stefan; Csük, René; Scotti, Luca; Deigner, Hans‐Peter

doi:10.1016/j.mtchem.2022.101176

Cited by 8 publications

(8 citation statements)

References 90 publications

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“…47 Compared to the literature, there are many studies with comparable pore sizes with ours. [48][49][50] It was also seen that there are studies of wound dressings, which have reported larger pore sizes than ours. 51,52 Especially considering the pathogen penetration, the pore sizes were evaluated as favorable.…”

Section: Morphological Observationssupporting

confidence: 68%

“…Pore size also gives the ability to prevent the pathogens from permeating to and colonizing the wound dressing, and eventually penetrating the live tissue 47 . Compared to the literature, there are many studies with comparable pore sizes with ours 48–50 . It was also seen that there are studies of wound dressings, which have reported larger pore sizes than ours 51,52 .…”

Section: Resultsmentioning

confidence: 74%

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Design of a bactericidal hydrogel scaffold containing genipin crosslinked HF‐18 peptide

Boncukcu

Akgul

Akmayan

et al. 2022

Biotechnology Progress

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Wound healing is a process getting affected by internal and external factors and might be interrupted by infections. To overcome infections during wound healing, novel antibacterial agents such as antimicrobial peptides have gained popularity because of the rising antibiotic resistance. Therefore, in this study, a three‐dimensional polymeric scaffold was designed for the controlled release of HF‐18 peptide, with the contribution of hyaluronic acid, chondroitin sulfate, and chitosan polymers with the crosslinker genipin. The obtained scaffold structure (OPT) was found to have interconnected pores, was pH‐responsive and swelled more in acidic conditions (5446.5% at pH: 5.0). It was observed that HF‐18‐loaded OPT (P‐OPT) was able to release HF‐18 peptide both in acidic and neutral conditions in a controlled release manner. This study also demonstrated that both OPT and P‐OPT were biocompatible and promoted L929 cell attachment and migration. Antimicrobial activity assessments demonstrated that P‐OPT was effectively bactericidal on Staphylococcus aureus and methicillin‐resistant S. aureus. Moreover, OPT produced a synergistic effect on the antimicrobial activity of HF‐18 peptide, as P‐OPT showed activity below the reported MIC value. As a result, OPT is considered a promising scaffold as a carrier for HF‐18 for wound healing.

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Section: Morphological Observationssupporting

confidence: 68%

Section: Resultsmentioning

confidence: 74%

Design of a bactericidal hydrogel scaffold containing genipin crosslinked HF‐18 peptide

Boncukcu

Akgul

Akmayan

et al. 2022

Biotechnology Progress

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“…[32][33][34] Borgolte et al synthesized chitosan derivatives substituted with BP groups as antibacterial coatings for polyether ether ketone (PEEK) substrates. 35 Following a similar design concept, Yoshikawa et al embedded BP in a polymer backbone incorporating a low fouling motif and cell adhesive peptide. The resulting coating showed substrateindependent behaviors and antifouling against bacteria.…”

Section: Discussionmentioning

confidence: 99%

A surface-independent bioglue using photo-crosslinkable benzophenone moiety

Shi,

Tao,

et al. 2024

RSC Adv.

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“…Therefore, biofilm formation was significantly reduced. Benzophenone is used to design anti-adhesive and antimicrobial surfaces with improved cell viability [143]. In another study, a traditional Chinese medicine-inspired compound, total alkaloids from Semen Strychnine (TASS), was used to enhance antibacterial properties.…”

Section: Coating With a Drug Carrier Materialsmentioning

confidence: 99%

Methods to improve antibacterial properties of PEEK: A review

Uysal,

Tezcaner,

Evis

2024

Biomed. Mater.

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As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, and in vivo methods. The mechanisms of bacterial inhibition by reactive oxygen species (ROS) generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.

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Synthesis of a biocompatible benzophenone-substituted chitosan hydrogel as novel coating for PEEK with extraordinary strong antibacterial and anti-biofilm properties

Cited by 8 publications

References 90 publications

Design of a bactericidal hydrogel scaffold containing genipin crosslinked HF‐18 peptide

Design of a bactericidal hydrogel scaffold containing genipin crosslinked HF‐18 peptide

A surface-independent bioglue using photo-crosslinkable benzophenone moiety

Methods to improve antibacterial properties of PEEK: A review

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