Synthesis of a common pentasaccharide moiety of diplasteriosides A and B belong to starfish asterosaponins isolated from the Diplasterias brucei

A Minireview on Biodiscovery in Antarctic Marine Benthic Invertebrates

“…Compounds with the ergostane skeleton are more hemolytically active than those with the cholestane one, and the presence of an additional methyl group at C 24 in the side chain of diplasterioside B causes reduction of its cytotoxic properties compared to diplasterioside A (Ivanchina et al, 2011). These compounds have already been synthesized by using Fmoc carbonate as an orthogonal protecting group which can be removed and the product subsequently glycosylated to reduce the number of steps (Sangwan et al, 2020). Finally, 19 steroids, 13 steroidal oligoglycosides, and six polyhydroxylated steroids are found in Acodontaster conspicuous, where half of them were active against at least one Antarctic marine bacterium (De Marino et al, 1997a), suggesting that they may play an important role in deterring microbial fouling and could be further investigated for potential antibiotic and antifouling properties.…”