Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase

The First 3‐Connected SrSi2‐Type 3D Chiral Framework Constructed from {Ni6PW9} Building Units

“…Upon cooling, the c m T value slowly increases to 21.39 cm 3 mol À1 K at 70 K, and then rapidly reaches the maximum of 62.86 cm 3 mol À1 K at 2 K. This magnetic behaviour suggests that overall ferromagnetic interactions exist between the Ni 2 + ions in 1. [15] The temperature dependence of the reciprocal susceptibility (1/c m ) obeys the Curie-Weiss law above 25 K ( Figure S7 in the Supporting Information) with a positive Weiss constant q = 13.07 K and Curie constant C = 17.14 cm 3 mol À1 K, which further supports the existence of overall ferromagnetic coupling between the Ni 2 + ions. In 1, the magnetic interactions within Ni 2 + ions are chiefly transmitted through the m 3 -O, m 3 -OH, and m 4 -O bridges.…”

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

“…( 378 ) A large number of inhibitors specifically targeted to DES have also been prepared and characterized. 379 − 383 …”

N-(4-Hydroxyphenyl)retinamide suppresses SARS-CoV-2 spike protein-mediated cell-cell fusion and viral infection in vitro 

“…Thus, DHCer, DHSM, and DHGlcCer are composed of saturated sphingoid base backbones (sphinganine), while Cer, SM, and GlcCer are composed of unsaturated sphingoid base backbones (sphingosine: Sph). Most of the genes encoding sphingolipid-metabolizing enzymes, as well as several inhibitors of sphingolipid-metabolizing enzymes, have been identi ed [14][15][16][17][18][19][20][21][22][23][24] . SARS-Cov-2 needs to penetrate the cell membrane in order to infect cells.…”