Synthesis of a functionalized tetrahydro-1,4-thiazepine in water as the solvent and theoretical investigation of its tautomeric structures

Synthesis of pyrimido[4′,5′:2,3][1,4]thiazepino[7,6-b]quinolines, derivatives of a novel ring system

“…Several heteroannulated analogues of this core fragment are also potent inhibitors of herpes simplex virus type 1 replication [7], show antihistamine activity [8], and are vasoconstrictor agents [9]. Various methods for the synthesis of fused 1,4-thiazepine derivatives have been reported in recent years with respect to their different structures [10][11][12][13][14][15][16][17][18]. Synthetic approaches to these compounds involve addition [19], condensation [20], coupling [21], rearrangement [22], and thermolysis [23] reactions in multistep syntheses.…”

Coumarin‐Based Bioactive Compounds: Facile Synthesis and Biological Evaluation of Coumarin‐Fused 1,4‐Thiazepines

“…Synthetic approaches to 1,4-thiazepine are varied and involve addition, condensation, coupling, rearrangement, and thermolysis methodologies in multistep synthesis (6). As a part of our ongoing studies on the synthesis of bioactive chromene and coumarin compounds (7)(8)(9)(10)(11)(12), herein, we wish to report the synthesis of novel 5-(2-hydroxyphenyl)-2,3-dihydro-1H-chromeno[4,3-e] [1,4]thiazepin-6(5H)-one derivatives (5a-e) using a simple method in two steps and their screening for antioxidant and cytotoxic activities.…”