Synthesis of a new class of retinoid, ³H‐labelled TTNPB, ¹ with a high specific activity

Abstract

propenyll-benzoic acid, (TTNPB), are described. Tritium was introduced by catalytic hydrogenation. The final product, TTNPB-3H2 (2). had a specific activity of 24.1 Ci/mmole and a radiochemical purity of 95.6%.

Synthesis of all‐trans‐[10′‐3H]‐8′‐apo‐β‐carotenoic acid

“…First, the polyolefinic nature of these compounds leads to their less than desirable stability, and thus introduction of radiolabels is generally limited to mild reactions. Although there is not a large body of literature on the synthesis of radiolabeled carotenoids (mostly biosynthesized by feeding of labeled precursors to various organisms), 30 [32][33][34][35][36] Secondly, their sensitivity to light forces the need to work in darkrooms with minimal red lighting and increases the technical difficulty of routine chemical manipulations.…”