Synthesis of a New Family of Ligands with Bispyrazole Structure. Reactivity of Bispyrazolylmethyl Ethers.

Abstract

PEREZ-MAYORAL, E.; GARCIA-AMO, M.; LOPEZ-LARRUBIA, P.; CERDAN, S.; BALLESTEROS*, P.; Heterocycles 65 (2005) 7, 1691-1704; Inst. Univ. Invest., Fac. Cienc., UNED, Ciudad Univ., E-28040 Madrid, Spain; Eng.) -Mais 45-147

Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast Agents

“…Chelators 17e-i were synthesized from the chloromethyl pyrazoles 18 prepared by condensation of the appropriate pyrazole with paraformaldehyde (Scheme 4) [21]. Compounds 18 were extremely reactive species, reacting with the corresponding nucleophiles to give different products, depending on the starting substrate.…”