Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents

Abstract

In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl ureido)-striazine (7a-i) and 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl thioureido)-s-triazine (8a-g). Antimicrobial properties of the title compounds were investigated against two Gram ( þ ve) bacteria (S. aureus, B. subtilis), two Gram (2ve) bacteria (P. aeruginosa, E. coli) and yeast-like fungi (C. albicans) using the broth microdilution method.

Synthesis, characterization, antiamoebic activity and cytotoxicity of novel series of pyrazoline derivatives bearing quinoline tail

“…In recent years it is reported that the incorporation of quinoline nucleus could alter the course of reaction as well as the biological properties [21,22]. Prompted by the above mentioned biological properties of pyrazoline and quinoline incorporating heterocycles, we here in report the synthesis of a novel series of pyrazoline derivatives (3ae3j) bearing quinoline tail.…”

Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents

“…In this synthetic endeavor, we decided to replace a chloro group with aryl urea ( 5a – k )/thiourea ( 6a – k ). We were guided to go for such replacement by the work done for substituted 2,4,6‐trichloro s ‐triazine derivatives 42–46 where the third chlorine atom of triazine was replaced by aryl urea/thiourea, assuming their reactivity as a nucleophiles.…”

Different Heterocycles Functionalized s‐Triazine Analogues: Design, Synthesis and In Vitro Antimicrobial, Antituberculosis, and Anti‐HIV Assessment

“…Compounds 2 ‐( methylthio )‐ 5 ‐( 3 , 4 , 5‐trimethoxyphenyl )‐ 1 , 3 , 4‐oxadiazole ( 6n ) and 5‐Pyridin‐4‐yl‐1 , 3 , 4‐oxadiazole‐2‐thiol ( 6o ) were synthesized by following the procedure described earlier .…”