2021
DOI: 10.1002/btpr.3132
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Synthesis of a novel nanocomposite containing chitosan as a three‐dimensional printed wound dressing technique: Emphasis on gene expression

Abstract: In this study, a highly porous three-dimensional (3D)-printed wound healing core/ shell scaffold fabricated using poly-lactic acid (PLA). The core of scaffold was composed of hyaluronic acid (HA), copper carbon dots (Cu-CDs), rosmarinic acid, and chitosan hydrogel. Cu-CDs were synthesized using ammonium hydrogen citrate under hydrothermal conditions. Formulation containing 1 mg ml −1 concentration of Cu-CDs showed an excellent antibacterial activity against gram bacteria. At 0.25 mg ml −1 of Cu-CDs concentrati… Show more

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Cited by 34 publications
(33 citation statements)
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“…The printed forms were produced by FDM using PLA, and the core of the scaffold was comprised of a mixture containing copper carbon ducts (Cu-CD), rosmarinic acid, hyaluronic acid, and chitosan hydrogel, by adding the mentioned mixture into the 3D printed scaffolds. The scaffold showed antibacterial activity, no cytotoxicity and good in vivo wound healing results, which was confirmed by gene expression of PDGF, TGF-β, and MMP-1 and histological analysis [139]. Hyaluronic acid was used in an innovative in situ printing system proposed by Hakimi and coworkers (2018).…”
Section: Metalsmentioning
confidence: 91%
“…The printed forms were produced by FDM using PLA, and the core of the scaffold was comprised of a mixture containing copper carbon ducts (Cu-CD), rosmarinic acid, hyaluronic acid, and chitosan hydrogel, by adding the mentioned mixture into the 3D printed scaffolds. The scaffold showed antibacterial activity, no cytotoxicity and good in vivo wound healing results, which was confirmed by gene expression of PDGF, TGF-β, and MMP-1 and histological analysis [139]. Hyaluronic acid was used in an innovative in situ printing system proposed by Hakimi and coworkers (2018).…”
Section: Metalsmentioning
confidence: 91%
“…: Cu-carbon dots, rosmarinic acid, chitosan), biocompatible polymers (i.e., PLA and chitosan), and a natural polymer existing in skin (hyaluronic acid). The resulting bionanocomposite scaffolds possess antimicrobial activity and non-toxicity, and significantly increase the expression of genes involved in wound healing (i.e., GAP, PDGF, TGF-β, and MMP-1), and improve wound healing properties in vivo [231]. Similarly, an antibacterial bioink based on alginate and methylcellulose, loaded with Ga +3 , was developed.…”
Section: Role Of Bioinks On Skin Bioprintingmentioning
confidence: 99%
“…In this manner, the antibacterial properties of the CDs can be supported on a solid phase, facilitating the removal or washing of the composite [ 110 ]. Many bactericidal applications of CD-composites rely on combining the photodynamic ROS production of the CDs with the antibiotic activity of a transition metal-based nanoparticle [ 111 ], often containing Ag [ 84 ], Cu [ 112 , 113 , 114 ], Zn [ 115 , 116 , 117 ], or Ti [ 118 ] oxides cores, among others. Moreover, CDs have been embedded within polymeric structures, including hydrogels and polymers of different natures, ranging from chitosan [ 119 , 120 ] to DNA [ 121 ], cellulose [ 122 ], gelatin [ 123 ], polyurethane [ 124 ], or poly lactic-co-glycolic acid nanoparticle [ 125 ] matrices.…”
Section: Cd-based Composite Materials For Antibacterial Applicationsmentioning
confidence: 99%