Synthesis of a novel water-soluble polyamide dendrimer based on a facile convergent method

Endo, Kojin; Ito, Yumiko; Higashihara, Tomoya; Ueda, Mitsuru

doi:10.1016/j.eurpolymj.2009.04.013

Cited by 12 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…p-Phenylenediamine (PDA) as the core structural unit reduces the steric hindrance between the two dendritic segments. Oligoethylene glycol (OEG) side chains were attached to the dendrimer's periphery through amide bond linkages [ 16 ] for the dual purpose of overcoming the dendrimer's limited solubility in methanol and providing greater hydrophilicity for membrane fouling resistance. These dendrimers were then deposited onto a commercial polyamide NF membrane (FLUID SYSTEMS TFC-S, Koch Membrane Systems, Wilmington, Massachusetts) for membrane modifi cation.…”

Section: Nanofi Ltration Membranes With Modifi Ed Active Layer Using mentioning

confidence: 99%

Nanofiltration Membranes with Modified Active Layer Using Aromatic Polyamide Dendrimers

Gao

Jubera

Mariñas

et al. 2012

Adv Funct Materials

View full text Add to dashboard Cite

The modification of a commercial nanofiltration (NF) membrane (TFC‐S) with shape‐persistent dendritic molecules is reported. Amphiphilic aromatic polyamide dendrimers (G1–G3) are synthesized via a divergent approach and used for membrane active layer modification by direct percolation. The permeate samples collected from the percolation experiments are analyzed by UV‐visible spectroscopy to monitor the influence of dendrimer generations on percolation behavior and active layer modification. Further characterization of modified membranes by Rutherford backscattering spectrometry and atomic force microscopy techniques reveals a relatively low‐level accumulation of dendrimers inside the original TFC‐S NF membrane active layer and subsequent formation of a coating of pure aramide dendrimers on top of the active layer. A PES‐PVA ultrafiltration membrane is used as a control membrane support (without an NF active layer) showing that structural compatibility between the dendrimers and support plays an important role in the membrane modification process. The performance of the modified TFC‐S membrane is evaluated on the basis of the rejection abilities for a variety of water contaminants having a range of molecular size and chemistry. As the water flux is inversely proportional to the thickness of the active layer, the amount of dendrimers deposited for specific contaminants are optimized to improve the solute rejection while maintaining high water flux.

show abstract

Section: Nanofi Ltration Membranes With Modifi Ed Active Layer Using mentioning

confidence: 99%

Nanofiltration Membranes with Modified Active Layer Using Aromatic Polyamide Dendrimers

Gao

Jubera

Mariñas

et al. 2012

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…The peripheral functional groups on dendrimers can be exploited based on their reactivity. Dendrimers are used in several areas including liquid crystals [60], catalysts [61] and photonic devices [62][63][64]. The dendrimer was first introduced into biomedical applications by Tomalia [65] in the 1990s.…”

Section: Poly(amidoamine)mentioning

confidence: 99%

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Boddu

Bhagav

Karla

et al. 2021

JFB

View full text Add to dashboard Cite

Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.

show abstract

“…Aqueous soluble polyamides can be structurally designed and used as proteinaceous materials to mimic natural proteins and provide unique cryoprotection for living cells, biologically active substances and food, as natural antifreeze proteins do . In addition, they have played important roles in metal chelation, ion exchange, drug delivery, fiber modification and inhibition of gas hydrate crystal growth in deep sea drilling . For preparation of water soluble polyamides, several methods can be used: (a) polycondensation of amino acids to form polypeptides and polyamides; (b) polymerization between certain hydrophilic diacids (or acid derivatives) and diamines; and (c) enzymatic production of certain poly(amino acid)s by bacteria …”

Section: Introductionmentioning

confidence: 99%

Preparation of aqueous soluble polyamides from renewable succinic acid and citric acid as a new approach to design bio‐inspired polymers

Jiang

Chen

et al. 2013

J of Applied Polymer Sci

View full text Add to dashboard Cite

A novel type of aqueous soluble polyamides were prepared as renewable substitutes for ecologically benign poly(aspartic acid) by polymerization of succinic acid ester and hexamethylene diamine in the presence of citric acid ester. The copolymerization resulted in the formation of poly(amide imide) intermediates, which were hydrolyzed to aqueous solutions of polyamides. The hydrolyzed products were confirmed to be copolymers of succinamide and citramide with COOH side chains, similar to poly(aspartic acid). The polyamides showed strong chelating abilities to Ca 21 and Pb 21 metals, comparable to poly(aspartic acid). Interestingly, they also demonstrated antifreeze activities in water by reducing the ice fractions. The polyamides represent a new class of metal chelators and antifreeze protein mimics derived from succinamide and citramide.

show abstract

Synthesis of a novel water-soluble polyamide dendrimer based on a facile convergent method

Cited by 12 publications

References 26 publications

Nanofiltration Membranes with Modified Active Layer Using Aromatic Polyamide Dendrimers

Nanofiltration Membranes with Modified Active Layer Using Aromatic Polyamide Dendrimers

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Preparation of aqueous soluble polyamides from renewable succinic acid and citric acid as a new approach to design bio‐inspired polymers

Contact Info

Product

Resources

About