Synthesis of a polyprenyl-type library containing 1,4-disubstituted-1,2,3-triazoles with anti-biofilm activities against Pseudoalteromonas sp.

Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles

“…This agrees with our results for fruits of the synonym Libidibia ferrea, which inhibited the formation of a biofilm by S. epidermidis by 70.0% (Table 2). Considering coumarins, we found only a few studies involving biofilm inhibition (Girennavar et al, 2008;Praud-Tabaries et al, 2009). However, antimicrobial activity of coumarins, terpenes (excluding volatile oils) and steroids against bacteria and fungi has been more widely described (Ojala et al, 2000;Sparg et al, 2004;Zhang et al, 2008;Popova et al, 2009;Smyth et al, 2009).…”

Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles

“…Isoprenyl 1,2,3-triazoles have shown promising and varied biological activities (Figure 2) such as antimicrobials, 9 antibiofilms, 10,11 antioxidants, 9 and antiparasitics. 12 Additionally they also displayed activity as geranylgeranyl transferase II, 13 geranylgeranyldiphosphate synthase, 14,15 farnesyltransferase, Ras and Rab geranylgeranyl transferase inhibitors.…”

Combinatorial Chemistry Online Volume 11, Issue 5, May 2009

“…biofilm. This process is suitable for combinatorial chemistry of marine natural product-like compounds 13 . A number of libraries have been produced to explore the potential of a 2,4-diaminopyridine lead.…”