Synthesis of a ruthenium(II) tryptophan-associated complex and biological evaluation against Ehrlich murine breast carcinoma

Porto, Hellen Karine Paes; Vilanova-Costa, Cesar Augusto Sam Tiago; Mello, Francyelli Mariana dos Santos; Costa, Wanderson; Lima, Aliny Pereira de; Pereira, Flávia de Castro; Almeida, M. A. P.; Graminha, Angélica E.; Batista, Alzir A.; Silveira-Lacerda, Elisângela de Paula

doi:10.1007/s11243-014-9882-1

Cited by 18 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FTIR med analysis allows us to evaluate that the L-trip molecule coordinates in a bidentate manner to the metallic center. This type of coordination fits well with that described for ruthenium L-trip compounds, [26] [32] covers [28] [33], platinum [34] [35], palladium [35], among others.…”

Section: Resultssupporting

confidence: 87%

See 1 more Smart Citation

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Tarso¹,

Dourado²,

Batista³

et al. 2020

ABC

View full text Add to dashboard Cite

To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl 4 (bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru +3 with bipy and L-trip. The spectroscopic characterization in the middle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl 2 (bipy)(L-trip)]1/2H 2 O. Evaluation of the antitumor potential of precursor K[RuCl 4 (bipy)] showed the toxic effects on MCF-7 cell line, but did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl 2 (bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.

show abstract

Section: Resultssupporting

confidence: 87%

“…[Ru(bipy) 2 (L-trip)]ClO 4 [26]. Amino acids can coordinate with transition metals in two ways, monodentate or bidentate, with the most frequent bidentate form being [31] [32]. Analysis of the above spectra gives strong evidence of the formation of the Ru-O and Ru-N bond with lymphatic amine nitrogen.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Tarso¹,

Dourado²,

Batista³

et al. 2020

ABC

View full text Add to dashboard Cite

show abstract

“…Our research group found that phosphinic ligands and other ligands with properties of biological interest, such as diimines, nitric oxide, carbon monoxide (CO) and amino acids coordinated to the ruthenium metal center, exhibited relevant characteristics in different biological assays (Barbosa et al, ; Lima et al, ; Mondelli et al, ; Oliveira et al, ; Porto et al, ; Santos et al, ). We have recently published a study demonstrating the antitumor activity of the ruthenium(II) compound, ct‐ [RuCl(CO)(dppb)(bipy)]PF 6 (where dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine), in in vitro and in vivo assays, as well as its interactions with ctDNA and bovine serum albumin.…”

Section: Introductionmentioning

confidence: 99%

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Carnizello

Alves

Pereira

et al. 2018

J of Applied Toxicology

View full text Add to dashboard Cite

Considering the promising previous results of ct‐[RuCl(CO)(dppb)(bipy)]PF6 (where dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine) as an antitumor agent, novel biological assays evaluating its toxicogenic potential were performed. The genotoxicity of the compound was evaluated by the in vitro micronucleus test (V79, Chinese hamster lung fibroblasts; HepG2, hepatocellular carcinoma cells), in vivo bone marrow micronucleus test and comet assay in hepatocytes (Swiss mice). The animals were treated with 0.63, 1.25, 2.5 and 5.0 mg/kg body weight (bw) of the compound. Negative (water) and positive (cisplatin, 1.5 mg/kg bw; methyl methanesulfonate, 40 mg/kg bw) controls were included. The parameters considered in the comet assay were the percentage of tail DNA, tail moment and tail length. The results of the in vitro micronucleus tests showed the absence of genotoxicity in V79 cells, while the compound was genotoxic in HepG2 cells at a concentration of 1.25 μm. In the in vivo micronucleus test, the compound was not genotoxic at the different doses evaluated. In the comet assay, only the dose of 5.0 mg/kg bw resulted in a significant increase in the frequency of DNA damage in hepatocytes when compared to the negative control. The genotoxic effect observed in HepG2 cells and in the liver comet assay indicates that the compound was metabolized by hepatic cells.

show abstract

“…The increasing antifungal activities of metal complexes were mainly attributed to the interaction between the metal ion and cell membrane. A reasonable illustration can be consulted in Tweedy's chelation theory [28,29]. Chelations partly decrease the polarity of the metal core in consequence of partial sharing of its positive charge with N-or O-containing ligand molecules.…”

Section: Antifungal Activity Studiesmentioning

confidence: 99%

Directed assembly of cobalt(II) 1-H-indazole-3-carboxylic acid coordination networks by bipyridine and its derivatives: structural versatility, electrochemical properties, and antifungal activity

Han

Qin

et al. 2015

J IRAN CHEM SOC

View full text Add to dashboard Cite

show abstract

Synthesis of a ruthenium(II) tryptophan-associated complex and biological evaluation against Ehrlich murine breast carcinoma

Cited by 18 publications

References 32 publications

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Directed assembly of cobalt(II) 1-H-indazole-3-carboxylic acid coordination networks by bipyridine and its derivatives: structural versatility, electrochemical properties, and antifungal activity

Contact Info

Product

Resources

About

Synthesis of a ruthenium(II) tryptophan-associated complex and biological evaluation against Ehrlich murine breast carcinoma

Cited by 18 publications

References 32 publications

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays

Directed assembly of cobalt(II) 1-H-indazole-3-carboxylic acid coordination networks by bipyridine and its derivatives: structural versatility, electrochemical properties, and antifungal activity

Contact Info

Product

Resources

About

Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct‐[RuCl(CO)(dppb)(bipy)]PF₆ [dppb = 1,4‐bis(diphenylphosphino)butane and bipy = 2,2′‐bipyridine], by in vitro and in vivo assays