Synthesis of a Semi-Interpenetrating Polymer Network as a Bioactive Curcumin Film

Abstract

Abstract. This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, and biocompatible film employed therapeutically as a wound healing platform. The semi-IPN films were investigated for their physicochemical, physicomechanical, and biological properties by quantification by FTIR, DSC, and Young's modulus. Following characterization, an optimum candidate formulation was produced whereby further in vitro and ex vivo studies were performed. Results revealed a burst release occurring at the first hour with 1.1 mg bioactive released when in contact with the dissolution medium and 2.23 mg due to bioactive permeation through the skin, thus suggesting that the lipophilic nature of skin greatly impacted the bioactive release rate. Furthermore, chemical and mechanical characterization and tensile strength analysis revealed that the degree of crosslinking and concentration of polymeric material used significantly influenced the properties of the film.

Interpenetrating polymer network as a pioneer drug delivery system: a review

“…Treatment of life-taking disease like cancer can be given by preparing IPN nanogels as a pH-sensitive factor used to formulate an intelligent system of therapeutic efficacy having capability of incorporating and delivering the agent of therapeutic importance, i.e., curcumin which is produced by the polymerization process of simple free radical emulsion for drug delivery applications in colorectal cancer treatment [43].…”

“…The process is commonly referred as PEGylation which involves the adsorption or the grafting the chains of PEG to the materials in the structure of polymeric nanoparticles that are applied for filtration of the blood instantaneously followed by injection to reside in circulation for long hours and indeed for the days. Longer the duration of particles in circulation, better the chances they possess to relate to tissues and components that are beneficial in the body [43]. IPN of egg white and carboxymethyl cellulose coated with folic acid-egg white loaded with cyclophosphamide as an anticancer drug was prepared as nanoparticles (NPs) and used for the treatment of breast cancer.…”

Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview

“…Consumption of genipin, a natural cross-linking agent in the drug delivery systems, is very common [45] in the TDDS as well. Genipin crosslinked chitosan film consisting of curcumin was formulated and evaluated and showed an excellent release of the curcumin [46]. In another study, this biocompatible, safe, non-toxic, cross-linking agent was used in the transdermal patches for the controlled delivery of marker drug, 4,4'-bis(2sulfostyryl) biphenyl [47].…”

Smart edible films based on mucilage of lallemantia iberica seed incorporated with curcumin for freshness monitoring

“…This property makes it appropriate for use in smart and intelligent packaging systems. Various studies have been carried out on the development of smart packaging systems incorporated by curcumin (Bajpai et al., 2015; Govindaraj et al., 2014; Mayet et al., 2014; Roy & Rhim, 2020; Wang et al., 2019).…”