Synthesis of a series of multivalent homo-, and heteroglycosides and their anti-adhesion activities

Li, Qing; Yan, Tingting; Niu, Shan; Zhao, Yuetao; Meng, Xiangbao; Zhao, Zhihui; Li, Zhongjun

doi:10.1016/j.carres.2013.06.011

Cited by 9 publications

(5 citation statements)

References 66 publications

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“…The contact angles of the 10 wt % PLGA/6 wt % PLGA/FA, 10 wt % PLGA/3 wt % PVP/FA, and 10 wt % PLGA/6 wt % PVP/FA nanofibers mats were 97, 78, and 53°, respectively. PLGA is hydrophobic, whereas PVP is hydrophilic, and hence, the 10 wt % PLGA/FA blend nanofiber membrane and 10 wt % PLGA/10 wt % PLGA/FA nanofiber membrane possessed poor hydrophilicity and a relatively large contact angle. When PLGA and PVP were coaxially electrospun in an ideal case, the PLGA shell completely wrapped the PVP core.…”

Section: Resultsmentioning

confidence: 99%

Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)–nanopoly(lactic‐co‐glycolic acid) core–shell composite nanofibers: Preparation, characterization, and anti‐adhesion activity

Zhu

Chen

et al. 2015

J of Applied Polymer Sci

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Flurbiprofen axetil (FA)-loaded coaxial electrospun poly(vinyl pyrrolidone) (PVP)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers were successfully fabricated by a facile coaxial electrospinning, and an electrospun drug-loaded system was formed for anti-adhesion applications. The FA, which is a kind of lipid microsphere nonsteroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed poly(lactic-co-glycolic acid) (PLGA)/PVP/FA composite nanofibers exhibited a uniform and smooth morphology. The cell viability assay and cell morphology observation revealed that the formed PLGA/PVP/FA composite nanofibers were cytocompatible. Importantly, the loaded FA within the PLGA/PVP coaxial nanofibers showed a sustained-release profile and anti-adhesion activity to inhibit the growth of the IEC-6 and NIH3T3 model cells. With the significantly reduced burst-release profile, good cytocompatibility, and anti-adhesion activity, the developed PLGA/PVP/FA composite nanofibers were proposed to be a promising material in the fields of tissue engineering and pharmaceutical science.

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Section: Resultsmentioning

confidence: 99%

Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)–nanopoly(lactic‐co‐glycolic acid) core–shell composite nanofibers: Preparation, characterization, and anti‐adhesion activity

Zhu

Chen

et al. 2015

J of Applied Polymer Sci

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“…For the investigation of the relationship between structural characteristics of homo-as well as heteroglycoclusters and anti-adhesion activity Li et al synthesized a series of homomultivalent and heteromultivalent cluster glycosides which were tested in a static cell-based adhesion assay. 82 It has previously been shown that multivalent lactosides can serve as valuable inhibitors for the adhesion of leukocytes to endothelial cells. 83 For targeting the responsible integrin CD11b on the surface of leukocytes, Li and co-workers compared divalent, tetravalent, hexavalent, and octavalent glycoclusters comprised of different combinations of glucose, galactose, mannose, cellobiose and lactose residues.…”

Section: Highlighting Secondary Structural Featuresmentioning

confidence: 99%

Organizing multivalency in carbohydrate recognition

2016

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The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.

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“…[24] After analyzing the data obtained, symmetric octavalent glycoconjugates (27-28) with lactose and D-mannose residues were synthesized in our laboratory to investigate anti-adhesive activity to the leukocytes.…”

Section: Glycodendrimers As Potential Therapeutic Agentsmentioning

confidence: 99%

“…After initial studies demonstrated a successful IgG/IgM response in mice, this construction is currently in clinical trials. [24] AntiInflammatory Activity of Glycodendrimers It has been reported earlier, the carbohydrates binding with peptides or lectins play very important role in the regulation of the biological processes. [47] The commonly used NSAIDs (Non Steroidal AntiInflammatory Drugs) are eliciting many side effects, such as dyspepsia, gastrointestinal bleeding, perforation in addition to renal trouble.…”

Section: Vaccines Based On Carbohydratesmentioning

confidence: 99%