2024
DOI: 10.1002/slct.202305073
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Synthesis of a Series of Quinoxaline Derivatives and Their Antibacterial Effectiveness Against Pathogenic Bacteria

Hena Khatoon,
Emilia Abdul Malek,
Siti Munirah Faudzi
et al.

Abstract: The pharmacological importance of quinoxaline derivatives in antibacterial research is well recognized. This study focuses on the synthesis of new 2,3‐dichloroquinoxaline derivatives containing thioether/ether groups to explore their potential as potent antibacterial agents against various pathogenic bacteria. Most of the compounds exhibited significant antibacterial properties comparable to the standard drug chlorhexidine (CHX). The derivatives of 2‐chloro‐3‐(arylthiol)quinoxaline demonstrated efficacy agains… Show more

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Cited by 5 publications
(1 citation statement)
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“…Quinoxaline, also called 1,4-diazanaphthalene, is a crucial core structure of various macrocyclic antibiotics such as echinomycin, levomycin, and actinoleutin that are known to inhibit growth of Gram-positive bacteria, and are active against various transplantable tumors. 1 A literature survey also discloses that quinoxaline derivatives have a wide spectrum of biological activities, such as antiviral, 2 anticancer, 3 and antibacterial activities. 4 In addition to biological and pharmaceutical effects, molecules containing the quinoxaline unit have been widely used in electroluminescent materials 5 and electrical/photochemical materials.…”
mentioning
confidence: 99%
“…Quinoxaline, also called 1,4-diazanaphthalene, is a crucial core structure of various macrocyclic antibiotics such as echinomycin, levomycin, and actinoleutin that are known to inhibit growth of Gram-positive bacteria, and are active against various transplantable tumors. 1 A literature survey also discloses that quinoxaline derivatives have a wide spectrum of biological activities, such as antiviral, 2 anticancer, 3 and antibacterial activities. 4 In addition to biological and pharmaceutical effects, molecules containing the quinoxaline unit have been widely used in electroluminescent materials 5 and electrical/photochemical materials.…”
mentioning
confidence: 99%