Synthesis of a Tripodal Scaffold for Solid Phase Synthesis of Artificial Receptors

Abstract

A convergent synthesis for the preparation of a new orthogonally protected tripodal scaffold has been developed. The scaffold was successfully coupled to a Tentagel solid support and further derivatised at the three attachment points demonstrating its possible use for combinatorial chemistry.

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

“…ninhydrin. If the amidation/esterification is complete, the Fmoc group can be released by piperidine and quantitatively detected by a well established UV measurement [322]. This in turn will give reliable data for initial -NH 2 /-OH loading (amount of a functional group on a resin generally expressed as mmol/g) of the resin.…”

Synthetic Approaches for Iron Type Chelators

“…Recently, Madder et al have also shown that despite the flexibility of the scaffold, the arms are organized in a parallel way providing a very good preorganization [19]. The synthesis is depicted in Scheme 2.…”

“…It was not a surprise to notice that the primary amine functions are not compatible with the aldehyde in (19): cyclisation readily occurred to produce the very stable bicyclic aminal (20) in 70% yield (Scheme 4a), but it was quite unexpected to notice that the nitrogen atom of amides (21) were also still enough nucleophilic to react similarly with the -CHO group (see Fig. (4b)).…”

“…The acid fluoride was chosen in place of the more usual acid chloride because it is more stable toward hydrolysis, it could be purified by CPL and characterized by 19 F NMR spectroscopy and hence it is more selective for the amide step formation. The acid fluoride was chosen in place of the more usual acid chloride because it is more stable toward hydrolysis, it could be purified by CPL and characterized by 19 F NMR spectroscopy and hence it is more selective for the amide step formation.…”

Rescuing Auxotrophic Microorganisms with Nonenzymatic Chemistry

“…[9] We then evaluated whether this transformation could take place in growth media. Using 20 µM [Cp*Ru(cod)Cl] ( 2 ) as a catalyst in PABA-free M9 glycerol minimal medium at 37 °C, we were able to detect formation of PABA from 100 µM 1 (Table 1, Entry 1).…”