2020
DOI: 10.22159/ijap.2020.v12s1.ff030
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Synthesis of Acetyl and Benzoyl Esters of Xanthorrhizol and Its Oxidation Products and Evaluation of Their Inhibitory Activity Against Nitric Oxide Production

Abstract: Objective: Xanthorrhizol is known to have anti-inflammatory activity. However, new xanthorrhizol derivatives with improved anti-inflammatoryactivity and reduced toxicity are needed.Methods: In this study, the derivatives of xanthorrhizol were synthesized and spectroscopically characterized, and their inhibitory activities againstnitric oxide (NO) production were evaluated in RAW 264.7 macrophage cells.Results: The first stage of synthesis produced compounds 2a and 2b in 58.49% and 63.26% yields, respectively. … Show more

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