Synthesis of Acetylated Dihydropyrimidine Analogues Under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers

A mini-review on Biginelli adducts with notable pharmacological properties

“…The acetylated thio -Biginelli adduct derivative 48 ( Fig. 4 ) effectively caused the relaxation of KCl-stimulated guinea pig ileum as attested by its value of negative log molar concentration of antagonist required to reduce the response of agonist by 50% (PA 2 = 6.06) in relation to the reference drug verapamil [19] .…”

Design, synthesis, and biological evaluation of thiourea and guanidine derivatives of pyrimidine-6-carboxylate

“…Bignelli reaction, a threecomponent cyclocondensation reaction, is one of the methods described to synthesize dihydropyrimidine derivatives [7]. Further, the dihydropyrimidine moiety has been considered as an important class of heterocyclic compounds exhibiting a variety of potent biological activities such as antiviral [8], antimicrobial [9], antioxidant [10], anti-inflammatory [11], anti-allergic [12], anticancer [13], calcium channel blockers [14], and antidiabetic, etc. [15].…”