In this study, the synthesis of the mesoporous mobile composite material No. 41 (MCM-41) modified with 3-aminopropyltriethoxysilane (APS) and chitosan (Cs) was carried out successfully to form novel Cs/MCM-41-APS nanocomposite (NC). It was also reported that its application as an adsorbent has removed aspirin from water. The structure and morphology of NC was Recently, water pollution has been a warning environmental problem due to pharmaceuticals [1] and personal care product residuals, [1,2] which are produced by homemade and hospital sewage, usage of over-the-counter drugs, and agricultural and industrial wastes, [3] These products are not biodegradable and are not easily degraded in the treatment process. [4] Among various pharmaceuticals pollutants, acetylsalicylic acid, also known as aspirin, is one of the non-steroidal and antiinflammatory drugs widely used by humans and