Synthesis of aliphatic 1,2-bishydroxylamines from 1,3- dihydroxyimidazolidines.

Derivatives of Dihydropyrazine-1,4-Dioxide, 3-Imidazoline 3-Oxide, and α-Phenyl Nitrones with Functional Groups as New Spin Traps in Solution and in the Gas Phase

“…2,5-Dihydropyrazine 1,4-dioxide ( 5 ) was synthesized by heating α-hydroxylamino oxime in acetone in the presence of an acid . 3-Imidazoline 3-oxides ( 16 , 18 , and 19 ) were obtained by condensation of the corresponding α-hydroxylamino oximes or α-amino oximes with benzaldehyde, acetone, or its diethyl ketal. ,, 1,2,2,5,5-Pentamethyl-3-imidazoline 3-oxide ( 17 ) was prepared by decarboxylation of 4-carboxy-1,2,2,5,5-pentamethyl-3-imidazoline 3-oxide , 2,3-Dihydropyrazine 1,4-dioxide ( 10 ) and hexahydroquinoxaline 1,4-dioxides ( 14 and 15 ) were obtained by the condensation of 1,2-bis(hydroxylamines) with glyoxal, phenyl glyoxal, and diacetyl .…”

Intramolecular Cyclization of 1,2-bis(N-alkoxy-N-nitrosoamino)alkanes: A Unique Route to 4,5-Dihydro-1,2,3-triazole 2-Oxides

“…N-Nitrosohydroxylamines have been previously shown to be quite capable of deamination reaction. 7 Furthermore, an 16,17 All spectral and physical data of the synthesized compounds are presented in the Table 3. The X-ray structures was solved using direct methods (SHELXS-86).…”

“…A series of new 1,2-bisalkoxyamines 4 both with an acyclic or alicyclic backbone was synthesized via acyl protection of hydroxylamino groups of the appropriate 1,2bishydroxylamines 1, 16,17 and alkylation followed by hydrolysis of the resulting cyclic diesters 3. Thus, reflux of 1,2-bishydroxylamines 1 with diethyl oxalate in ethanol gave the corresponding cyclic bishydroxamic acids 2 in a 80-90% yield.…”

Synthesis and Inhibitory Effect on Platelet Aggregation and Antihypertensive Activity of 1-Hydroxy-2,5-dihydro-1H-imidazole-2- carboxylic Acid 3-Oxides, 1,3-Dihydroxyimidazolidine-2-carboxylic Acids, and 1,4-Dihydroxy-2,3-piperazinediones

“…As a part of our systematic study of 1,2-hydroxylaminooximes [1] 1 and their hydrogenated derivatives -1,2-bishydroxylamines [2] 4 -we have explored the reaction of 1 and 4 with glyoxylic and pyruvic acids to obtain potential biologically active imidazole 2 and imidazolidine 5 carboxylic acids. These compounds were tested for platelet aggregation and antihypertensive activity.…”